GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2243480 | 1 | rs7795242 | chr7:65390094 | CCT6P1 | chr7:65216092-65228661:+ | 0.67 | 4.9 | 3.88E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs7804223 | chr7:65664559 | CCT6P1 | chr7:65216092-65228661:+ | -0.68 | -5.66 | 1.6E-7 | Diabetic kidney disease |
| THYM | cis | rs11799420 | 1 | rs78075821 | chr1:171724645 | VAMP4 | chr1:171669298-171711214:- | 0.34 | 4.39 | 2.94E-5 | Hippocampal atrophy |
| THYM | cis | rs2243480 | 1 | rs781142 | chr7:65438778 | CCT6P1 | chr7:65216092-65228661:+ | 0.63 | 5.29 | 7.94E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs781149 | chr7:65481284 | CCT6P1 | chr7:65216092-65228661:+ | 0.61 | 5.07 | 1.93E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs781150 | chr7:65480973 | CCT6P1 | chr7:65216092-65228661:+ | 0.65 | 5.41 | 4.64E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs781156 | chr7:65479141 | CCT6P1 | chr7:65216092-65228661:+ | 0.65 | 5.41 | 4.64E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs781157 | chr7:65478311 | CCT6P1 | chr7:65216092-65228661:+ | 0.6 | 4.98 | 2.86E-6 | Diabetic kidney disease |
| THYM | cis | rs2143950 | 1 | rs78207779 | chr14:35506387 | PPP2R3C | chr14:35554679-35591679:- | 0.26 | 4.87 | 4.53E-6 | Atopic dermatitis |
| THYM | cis | rs7822232 | 1 | rs7822232 | chr8:145145687 | KIAA1875 | chr8:145162629-145173218:+ | -0.8 | -4.4 | 2.79E-5 | Blood metabolite levels |
| THYM | cis | rs11723261 | 1 | rs78343340 | chr4:267437 | ZNF718 | chr4:53272-156488:+ | 0.65 | 7.31 | 8.46E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs6911965 | 1 | rs78420872 | chr6:24464429 | GPLD1 | chr6:24428405-24489850:- | 0.59 | 5.4 | 4.83E-7 | Hematological and biochemical traits |
| THYM | cis | rs7849270 | 1 | rs7849160 | chr9:131874552 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.61 | 1.24E-5 | Blood metabolite ratios |
| THYM | cis | rs7849270 | 1 | rs7849270 | chr9:131874641 | CRAT | chr9:131857075-131873070:- | 0.4 | 4.91 | 3.82E-6 | Blood metabolite ratios |
| THYM | cis | rs2275426 | 1 | rs785464 | chr1:46523089 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |